Benefit of drinking green tea: The proof is in -- drinking tea is healthy, says Harvard Women’s Health Watch

September 2004

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Although tea drinking has been associated with health benefits for centuries, only in recent years have its medicinal properties been investigated scientifically. The October issue of Harvard Women's Health Watch recognizes the healthy power of tea while helping readers get the most out of their cups.
Tea's health benefits are largely due to its high content of flavonoids — plant-derived compounds that are antioxidants. Green tea is the best food source of a group called catechins. In test tubes, catechins are more powerful than vitamins C and E in halting oxidative damage to cells and appear to have other disease-fighting properties. Studies have found an association between consuming green tea and a reduced risk for several cancers, including, skin, breast, lung, colon, esophageal, and bladder.
Additional benefits for regular consumers of green and black teas include a reduced risk for heart disease. The antioxidants in green, black, and oolong teas can help block the oxidation of LDL (bad) cholesterol, increase HDL (good) cholesterol and improve artery function. A Chinese study published recently in the Archives of Internal Medicine showed a 46%-65% reduction in hypertension risk in regular consumers of oolong or green tea, compared to non-consumers of tea.




The October issue provides a few tips to get the most out of tea-drinking:
Drinking a cup of tea a few times a day to absorb antioxidants and other healthful plant compounds. In green-tea drinking cultures, the usual amount is three cups per day. Allow tea to steep for three to five minutes to bring out its catechins. The best way to get the catechins and other flavonoids in tea is to drink it freshly brewed. Decaffeinated, bottled ready-to-drink tea preparations, and instant teas have less of these compounds. Tea can impede the absorption of iron from fruits and vegetables. Adding lemon or milk or drinking tea between meals will counteract this problem.
 

September 2004
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Is Job Stress Aging You Faster?

August 13, 2012

A stressful job can shorten telomeres and lead to faster aging.

T.G.I.M.—Thank Goodness It’s Monday. Now, that’s something you don’t hear very often. For most people, the start of a new week means returning to the daily grind: work, stress, and exhaustion. Now research shows that work-related exhaustion hurts you more than you think—it can actually shorten the length of telomeres, which speeds up aging.
The study, published in PLoS One, used data from the Health 2000 Study and consisted of 2,911 Finnish men and women aged 30-64. Results showed that 18 percent of subjects had mild work-related exhaustion while 5 percent had severe work-related exhaustion. Interestingly, severe exhaustion was most common among female, unmarried, manual laborers, and ill workers.
Work-related exhaustion was assessed using a reliable and valid measure of occupational burnout. The average summary score was calculated as no exhaustion, mild exhaustion, or severe exhaustion.
Comparing telomere length to the results of the work-related exhaustion survey showed that those with severe exhaustion had significantly shorter telomeres than those with mild or no exhaustion. The results remained significant even after adjustment for marital status, occupation type, daily smoking, body mass index (BMI), physical illness, and common mental disorders.
Telomeres protect the genetic information within cells by acting as caps at chromosomal ends. Over time, telomeres gradually shorten leading to DNA damage and cell death. Because of this relationship, the length of telomeres can serve as a biomarker for biological age.
Similar to previous research, this study suggested that age, sex, and BMI are related to telomere length. Also, men, older people, and obese people had shorter white blood cell (leukocyte) telomeres than others.
General recommendations to protect DNA are to exercise regularly, eat a balanced diet, and avoid smoking. Now, add to the list adopting a stress-free work environment. For most people, that is easier said than done.
Not to worry—Isagenix has your back. Supplementation with Ionix Supreme and Ageless Essentials Daily Pack with Product B can protect your telomeres by fighting the effects of stress and exhaustion. Take a deep breath, relax, and nourish your body with Isagenix.
Reference: Ahola K, Siren I, Kivimaki M et al. Work-related exhaustion and telomere length: a population-based study. PLoS One 2012;7:e40186. Doi: 10.137/journal/pone.0040186

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Chocolate is Unfailingly Good for Your Heart

Chocolate is a heart-healthy Valentine's gift, according to a systematic review

A box of chocolates this Valentine’s Day may be key for a long-lasting, healthy relationship… and heart, according to a systematic review and meta-analysis just published in the American Journal of Clinical Nutrition.

The study pooled data from 42 randomized controlled trials that included 1,297 subjects and found consistent short- and long-term cardiovascular benefits from intake of chocolate, cocoa, or cocoa flavanols—the antioxidant components of chocolate. Chocolate eating was associated with better toned blood vessels, blood flow, and maintenance of blood pressure. Additionally, chocolate eating was linked to better insulin sensitivity, a previously unreported finding.

The researchers evaluated several effects of cocoa flavanols on cardiovascular risk factors such as blood vessel elasticity (endothelial function), inflammation, and platelet function. Notably, chocolate appeared to help blood vessels become more elastic and flexible regardless of how much eaten per day.For most of us, the quantity of chocolate we eat is not a problem, but as usual, quality is the key. The study results are no reason to over-indulge in chocolate, the authors caution, as the sugar-and-fat calories can quickly add up. Unless the goal is to gain weight, there still needs to be moderation in chocolate-eating habits.

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Getting cardiovascular benefits from chocolate can be as simple as eating a couple or more pieces of IsaDelight Plus Dark Chocolates, specially formulated to be rich in antioxidant flavanols yet be low in calories. The chocolates also come packed with metabolism-boosting green tea extract and brain-supporting amino acids to assist in weight management. Healthy snacking never tasted so good!

Feeling bitter about dark chocolate for your Valentine? Give your sweetie a sweeter version with the new IsaDelight Plus Milk Chocolates. Still packed with cocoa flavanols, green tea extract, and amino acids, IsaDelight Plus Milk Chocolates offer a delicious, antioxidant-rich alternative.

For chocolate lovers, the additional evidence confirming cocoa’s heart-health benefits is great news. However, note that chocolate will not undo years of inactivity and a poor diet. Yet it can help jump-start the journey towards a healthier heart and overall you, especially when combined with Cleanse Days and Shake Days of an Isagenix system.

Reference

Hooper L et al. effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 2012; doi: 10.3945/ajcn.111.023457.

Environmental Pollution Linked to Short Telomeres

April 17, 2012

Research has found that Italian women living near illegal toxic waste dumps have shorter telomeres.

Living too close to a landfill containing hazardous waste is associated with premature aging at the level of telomeres, according to a new study from University of Naples Federico II in Italy.

The length of telomeres, protective caps on the ends of chromosomes, is considered a biological marker of aging. Telomeres shorten with age and when exposed to oxidative stress, the amount of which can be raised by a number of factors including environmental pollution.

To evaluate how environmental pollution can affect telomeres, the Italian researchers evaluated blood samples of 50 pregnant women who lived in close proximity to illegal hazardous waste dumps in Italy’s Campania region.They found that the women had significantly shorter telomeres compared to women living in other areas free of the landfills. In addition, the women who lived closest to the dumps were most likely to have short telomeres.

The researchers also reported that low activity of the enzyme telomerase—necessary to maintain telomere length integrity—was detected in the pollution-exposed women as well.

“These findings may have implications for understanding how, at the cellular level, environmental stress may promote earlier onset of age-related diseases,” wrote the researchers, who published their findings in Gene.

Italy’s Campania region—between Acerra, Nola, and Marigliano—has been dubbed the “triangle of death” because of reports of an unusually high number of deaths from cancer (as well as birth defects). Illegal hazardous waste dumping in the region is thought to contribute to these deaths. There are an estimated 1,230 illegal hazardous waste dumps in the area.

The research may be used to implicate the local illegal dumping as a health hazard and steer enforcement of landfill regulations in the region.

According to an article in New Scientist, industrial waste products called dioxins may be to blame for the effect on telomeres. Dioxins are dangerous chemicals found widely in the environment that are linked to interfering with hormones, reproductive problems, and chronic diseases. Short telomeres have been linked to several age-related diseases including cardiovascular disease, Alzheimer’s disease, and some cancers.

According to the World Health Organization, more than 90 percent of the exposure to dioxins in humans is from foods such as meat, dairy, fish, and shellfish. For this reason, governments have programs in place to monitor the food supply for dioxins.

Reference: Felice BD, et al. Telomere shortening in women resident close to waste landfill sites. Gene. 2012 March 20 [Epub ahead of print]. doi:

http://dx.doi.org/10.1016/j.gene.2012.03.040

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Fructose Is Not “Toxic” and Can Help Control Blood Sugar

February 29, 2012

Fructose is healthy at levels found in fruits, new research confirms.

Fructose, found naturally in fruits and vegetables, has been unfairly singled out as a scapegoat for the obesity epidemic, Canadian researchers say.

The sugar is not “toxic,” does not cause weight gain any different than any other source of carbohydrate when consumed in excess, does not affect blood pressure any differently, and can even help manage blood sugar when consumed in amounts normally obtained from fruit. These were the findings of three extensive systematic reviews that analyzed well-designed randomized controlled feeding trials to evaluate the effects of fructose as compared to other sources of carbohydrates.

These meta-analyses revealed the following:

• Fructose had no significant effect on body weight in an analysis of 31 calorie-controlled trials. Excess calories coming from any source of carbohydrates contributed to weight gain regardless of type.
• Fructose demonstrated no adverse effect on blood pressure when compared to other carbohydrate sources in an analysis of 15 trials, contrary to previously raised concerns.
• Some fructose, up to and around 10 grams per meal, could improve glycemic control (blood sugar control), according to analysis of six trials.

The authors caution that fructose at high doses such as found in many sugar-sweetened sodas (often 25 grams or higher) can increase body weight. However, the weight gain would be attributed to the extra calories consumed and not because of any unique property of fructose.

John L. Sievenpiper, M.D., Ph.D., Russel J. de Souza, ScD, RD, and David Jenkins, M.D., Ph.D., D.Sc., from St. Michael’s Hospital in Toronto, Ontario, Canada, along with their research team published their findings in the February issues of Annals of Internal Medicine, the British Journal of Nutrition, and Hypertension. 

Funding for their research came primarily from the Canadian Institutes of Health Research.

Fructose is often singled out in the popular press because of the prominence of high-fructose corn syrup, which is about 45 percent glucose and 55 percent fructose, in a variety of processed foods. Notably, in these reviews, the researchers concentrated on fructose only and excluded studies on high-fructose corn syrup.

The research is presented in the face of controversy because of a previously published commentary in Nature authored by Robert Lustig, M.D., and colleagues, in which they described the sugar as “toxic.” In response to Lustig’s paper, Sievenpiper, de Souza, and Jenkins wrote to the publication saying:

Robert Lustig and colleagues argue that sugar is “toxic,” focusing on the “deadly effect” of the fructose moiety of sucrose. But they are directing attention away from the problem of general overconsumption.

Guidelines on healthy eating encourage fruit consumption, and fruit and fruit products are the third-largest source of fructose in the US diet.

Our meta-analyses of controlled feeding trials indicate a net metabolic benefit, with no harmful effects, from fructose at a level of intake obtainable from fruit.

Their criticism was published as “Correspondence” in the 23 February issue ofNature  accompanied by comments of other scientists. The other comments called the “opinion paper” of Lustig and colleagues “extreme,” “ludicrous,” and “sensationalism.” They also made the point that the paper contained oversimplifications that sought to demonize sugar rather than address the complex factors (such as overeating and sedentary lifestyle) associated with obesity in a way that would serve public health.

In their comment, clinical nutritionists Christiani Jeyakumar Henry, Ph.D., and Viren Ranawana, Ph.D., of the Singapore Institute, wrote that “contribution of sugar towards chronic diseases is more relevant to developed countries than the developing world,” and that it’s more likely that overconsumption of high-glycemic carbohydrates are what mainly contribute to obesity and diabetes.

Fructose, unlike other sugars, is low glycemic because it's metabolized differently.

Fructose, metabolized differently than glucose and other sugars, doesn’t stimulate insulin and is characteristicallylow glycemic. For these reasons, it’s often used in low-glycemic food applications (and mainly in amounts similar to what’s in fruit). It’s also higher in stability and perceived sweetness compared to other sugars, which leads to less use of sugar overall.

References

Sievenpiper JL, de Souza RJ, Mirrahimi A et al. Effect of Fructose on Body Weight in Controlled Feeding Trials: A Systematic Review and Meta-analysis. Ann Intern Med2012;156:291-304.

Sievenpiper JL, Chiavaroli L, de Souza RJ et al. ‘Catalytic’ doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: a small meta-analysis of randomised controlled feeding trials. Br J Nutr 2012;1-6. doi:10.1017/S000711451200013X

Ha V, Sievenpiper JL, de Souza RJ et al. Effect of Fructose on Blood Pressure: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. Hypertension 2012. doi: 10.1161/​HYPERTENSIONAHA.111.182311

Lustig RH, Schmidt LA, Brindis CD. “Public health: The toxic truth about sugar.” Nature482, 27-29 (02 February 2012). doi: 10.1038/482027a

Sievenpiper JL, de Souza RJ, Jenkins DJA. “Sugar: fruit fructose is still healthy.” Correspondence. Nature 482, 470 (23 February 2012) doi: 10.1038/482470e

Henry CJ, Ranawana V. “Sugar: a problem of developed countries.” Correspondence. Nature 482 (23 February 2012) doi: 10.1038/482471a 

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